A multi-institutional team led by Argonne has been named a finalist for the Association for Computing Machinery’s Gordon Bell Prize for a breakthrough in computational protein design. Researchers developed MProt-DPO, a system that streamlines the design of proteins by focusing on desired traits such as stability and functionality. The innovation lies in its ability to operate on exascale supercomputers that perform over a quintillion calculations per second. This approach accelerates drug discovery and bioengineering by handling vast, complex datasets in record time.