Now in its fifth year, the Extreme-Scale Experiment-in-the-Loop Computing (XLOOP) workshop focuses on the intersection of HPC and large-scale experimental science. Chaired by Argonne’s Justin Wozniak and Nicholas Schwarz, the XLOOP workshop will feature papers and presentations detailing how advances in computing, including new AI data transfer methods, are helping to accelerate discoveries by integrating HPC resources with observational and experimental facilities.